ABM as a cellular health Promotor

Agaricus blazei (ABM) has demonstrated a variety of ways it promotes cellular health. In vitro research has shown that ABM can induce apoptosis (shut down) unhealthy cells of the blood(1), ovaries(2), and fibrous connective tissue(3). In vitro research demonstrated ABM prevented the development of unhealthy cells of the liver(4).

Further in vitro research revealed that ABM had a protective effect on cells exposed to radiation(5) as well as cells exposed to the toxic chemical methyl methanesulphonate(6). In vitro research also demonstrated that healthy cells exposed to ABM were not damaged or adversly affected by ABM(7)(8)(9).

Reference:
1.Gao L, Sun Y, Chen C, Xi Y, Wang J, Wang Z (November 2007), "Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-β prepared from the mushroom Agaricus blazei Murill", Braz J Med Biol Res 40 (11): 1545–1555, doi:10.1590/S0100-879X2006005000181, PMID 17934651
2.Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T (August 2005), "Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model", J Cancer Res Clin Oncol (Berlin; Heidelberg: Springer) 131 (8): 527–538, doi:10.1007/s00432-005-0672-1, PMID 15883813
3.Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R (May 1998), "Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricusblazei Murill, mediated via natural killer cell activation and apoptosis.", Cancer Immunol Immunother (Springer Verlag) 46 (3): 147–159, doi:10.1007/s002620050473, PMID 9625538
4.Sorimachi K, Akimoto K, Koge T (February 2008), "Inhibitory effect of Agaricus blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells", Biosci Biotechnol Biochem 72 (2): 621–623, doi:10.1271/bbb.70700, PMID 18256462
5.Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H (March 2005), "Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death", Int J Mol Med (Athens: D.A. Spandidos) 15 (3): 401–406, OCLC 39728400, PMID 15702228
6.Luiz RC, Jordão BQ, da Eira AF, Ribeiro LR, Mantovani MS (25 July 2003), "Mechanism of anticlastogenicity of Agaricus blazei Murill mushroom organic extracts in wild type CHO (K(1)) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays", Mutat Res (Amsterdam: Elsevier) 528 (1–2): 75–79, OCLC 1590350, PMID 12873725
7.Lee IP, Kang BH, Roh JK, Kim JR (January 2008), "Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.", Food Chem Toxicol (New York: Pergamon) 46 (1): 87–95, doi:10.1016/j.fct.2007.07.001, PMID 17707568
8.Martins de Oliveira J, Jordão BQ, Ribeiro LR, Ferreira da Eira A, Mantovani MS (December 2002), "Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro", Food Chem Toxicol (New York: Pergamon) 40 (12): 1775–1780, doi:10.1016/S0278-6915(02)00156-4, PMID 12419691
9.Bellini MF, Giacomini NL, Eira AF, Ribeiro LR, Mantovani MS (August 2003), "Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom", Toxicol in Vitro (Oxford; New York: Pergamon) 17 (4): 465–9, doi:10.1016/S0887-2333(03)00043-2, OCLC 13144158, PMID 12849730